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People with a substance use disorder (SUD) at any time in their lives are 1.5 times more likely to contract COVID-19 than those without an SUD, and those with a...
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Animal studies suggest that subjects with HIV who suffer from opioid use disorders may have higher viral reservoirs in the central nervous system than non-opioid users.
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Patients in treatment for opioid use disorder (OUD) who were more comfortable making decisions when they did not know the probability of outcome had a higher risk of using opioids...
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These reviews address how each of these addictive substances and HIV individually or collectively affect the immune system and subsequent clinical and behavioral outcomes
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A specific collection of neurons in the basolateral amygdala, a brain region crucial for affect, was active when mice experienced pain. Deactivating this collection of neurons resulted in a loss...
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In the summer of 2019, Dr. Linda Dwoskin and her research team felt they were in a promising place in their decades-long search for a treatment for the 700,000 Americans...
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Substance use is common among people living with HIV and is associated with less successful HIV treatment outcomes. Integrating substance use services into HIV care is a promising strategy to...
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Cocaine can trigger release of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the ventral tegmental area of the midbrain in mice, and this may play a role in cocaine use disorder.
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Prenatal cannabis exposure (PCE) increased sensitivity to THC in male rats, but not female rats, during pre-adolescence. PCE increased dopamine release in response to THC and altered the properties of...
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Activity in the striatum of people who smoke changed less in response to positive feedback/reward than in nonsmokers; this effect was more pronounced with greater addiction severity. Activity of the...
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Concerted efforts and substantial investments in HIV prevention and care in the United States have resulted in considerable reduction in new diagnoses and death since the mid-1990s. To identify best...
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This study found that children’s risk of marijuana and alcohol use and attitudes toward marijuana were influenced by their parents’ marijuana use pattern over time.
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People with substance use disorders (SUD) can be at high risk for contracting this virus, either through injection drug use, or risky behaviors prompted by impaired judgment.
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International research teams analyzed several hundred thousand samples from 17 whole-exome sequencing studies to identify rare gene variants associated with smoking and alcohol use. They identified rare variants in 117...
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A new computational analysis suggests certain dopamine receptors in the brain and body are more complex and dynamic than previously thought, existing in diverse inactive states that only allow the...
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Rats with a disrupted transcription factor 7-like 2 (Tcf7l2) gene in the medial habenula showed markedly greater nicotine intake than control rats. Reduced Tcf7l2 expression in the medial habenula reduced...
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The National Institute on Drug Abuse (NIDA) has launched a redesigned series of booklets geared towards educating middle school students about substance use. The Mind Matters series consists of nine...
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Just published research by scientists at NIDA’s Intramural Research Program reveals that the drug cocaine causes neurons to synthesize endocannabinoids that are then enclosed within membrane-bound packages, known as extracellular...
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With nearly $290M of new funding for seven years to research institutions around the country, the National Institutes of Health renewed its commitment to the Adolescent Brain Cognitive Development (ABCD)...