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NIDA

Overdose drug shows promise as stroke treatment

Science Highlight

April 17, 2018

Naloxone, the life-saving drug used to treat opioid overdose, is shown to reduce brain inflammation in the aftermath of stroke in male rats. The preclinical research, by scientists at the NIDA Intramural Research Program, partnering with investigators from Colorado, Taiwan and Finland, lays the groundwork for developing the first drug to promote recovery from ischemic stroke, a leading cause of adult disability.

Post-stroke intranasal naloxone decreases microglial activation, a sign of inflammation in the brain ​Post-stroke intranasal (+)-naloxone decreases microglial activation, a sign of inflammation in the brain, in the striatum and thalamus.Photo courtesy of Airavaara Lab, University of Helsinki.

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