This study found that HIV-1 could be eliminated in mice using a combination of two antiviral technologies—long-acting viral reservoir–targeted antiretroviral therapy and CRISPR/Cas-9 gene editing. HIV was undetectable in 9 out of 23 mice that received the combination treatment. HIV was not eliminated in any of the mice that were given either treatment alone.
In this international trial, participants who received the intervention engaged in HIV treatment, achieved viral suppression at higher rates, and died at half the rate of participants in a control group.
September 2017 Inhibiting mTOR, a regulatory protein complex, can prevent reactivation of latent HIV. Medications to inhibit mTOR might help people with HIV achieve and maintain undetectable HIV viral loads.