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NIDA Notes Articles: Genetics
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Transcription Factor E2F3a Mediates Cocaine’s Effects on Gene Expression and Addiction-Related Behaviors

February 2019
This study demonstrated that cocaine increases expression of the protein E2F3a in the brain’s reward system. The changes in E2F3a levels in the nucleus accumbens are tied to addiction-related behaviors and to altered gene expression.

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How Cocaine Cues Get Planted in the Brain

September 2018
An epigenetic mechanism underlies the powerful cocaine–environment associations that promote relapse.

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A New Tool for Investigating HIV in the Brain

August 2018
Researchers developed a tool that enables them to closely monitor HIV activity in key brain cells. The tool may accelerate the development of treatments for HIV in the brain.

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A Gene Links Impulsivity and Drug Use Vulnerability

June 2018
Understanding the relationships between impulsivity and drug use vulnerability may help identify new ways of treating or preventing substance use disorders.

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Gene Variant Is Associated With Reduced HIV Transmission

March 2016
A gene variant appears to partially shield people whose behaviors entail high risk for exposure to human immunodeficiency virus (HIV) from becoming infected.

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