The placenta is the main transporter of nutrient, metabolites, and substances to the fetus. It is a complex barrier organ that maintains the separate intrauterine fetal environment from the mother while also transporting fetal metabolites and waste back to the mother. Placenta activities and functions impact fetal brain development in all stages of pregnancy. Growing evidence suggests that various abused substances, such as tobacco, cannabinoids, opioids, and alcohol, alter placental structures, activities, and functions. However, knowledge on how these substances affect placenta differentiation and growth, and how such responses by placenta impact its barrier and transportation functions, remain limited. The cellular, molecular, and anatomical changes of placenta caused by abused substances, are poorly understood.
In addition, the pharmacokinetics and pharmacodynamics of various substances that are taken up by and cross the placenta, the effective quantity of substances and their metabolites that reach the fetal side of the circulation, and their consequences for fetal development are unknown.
This workshop includes four sessions that will cover Clinical Research, Basic Research and Animal Modeling, Genetics and Epigenetics, and Emerging Technologies. Part of the workshop is jointly organized with staff from NICHD, the sponsoring institute of the successful Human Placenta Project. The workshop will highlight the current state and discoveries of placenta research in the context of in-utero substance exposure. It will also identify barriers and challenges to placenta research, and opportunities and strategies to address these barriers and challenges.
|11:00 am||Welcome and Introduction of Speakers and Discussants|
|11:10 am||Opening Remarks and Charge to the Workshop - Dr. Rita Valentino, Director of Division of Neuroscience and Behavior, NIDA|
Session One: Clinical Research
Francesco Busardó, Associate Professor, University Politecnica delle Marche of Ancona, Italy https://www.researchgate.net/profile/Francesco-Busardo
Jashvant Unadkat, Professor, University of Washington
|12: 25 pm||
Session Two: Basic Research and Animal Modeling
Qingcheng Mao, Associate Professor, University of Washington
Cheryl Rosenfeld, Professor, University of Missouri
|1: 35 pm||
Session Three: Genetics and Epigenetics
Melissa A. Suter, Assistant Professor, Baylor College of Medicine
Elisha Wachman, Associate Professor, Boston Medical Center
|2: 45 pm||
Session Four: Emerging Technologies
Lauren Aleksunes, Professor, Rutgers University
Irina Buhimschi, Professor, University of Illinois at Chicago (UIC)
- Laura Stroud, Professor, Brown University
- Carmen Marsit, Professor, Emory University
- Joseph Cheer, Professor, University of Maryland
- Elizabeth S. Taglauer, Assistant Professor, Boston University
- Simona Pichini, Analytical Pharmacotoxicology Unit Head, National Centre on
- Addiction and Doping, Istituto Superiore di Sanità, Italy
- Da-Yu Wu, NIDA
- Matthew Seager, NIDA
- David Weinberg, NICHD
Questions to be addressed by the workshop include:
- The roles and consequences of placenta in fetal substances exposure.
- Cellular and molecular changes of placenta, including dysregulation of trophoblasts, receptors, transporters and enzymes, and changes of structures, activities and functions in response to abused substances.
- The uptake, metabolism and transport of substances by placenta, and the cellular and molecular mechanisms underlying placenta barrier and/or transport functions for substances from mother to fetus.
- Genetic and epigenetic changes of placenta due to substance exposure during pregnancy, and their roles and consequences in fetal development.
- Innovative technologies for the precise detection and quantitation of fetal substances exposure through placenta.
- Biomarkers, circulating extracellular vesicles and other factors associated with substance exposure in mother and fetus though placenta.
- Opportunities and emerging technologies to meet the challenges in placenta studies for fetal substance exposure.
Meeting number: 182 661 5583
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